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Primary Faculty
Contact
- Department of Biology
- 229 Gilmer Hall
- 485 McCormick Road
- P.O. Box 400328
- Charlottesville, VA 22904
ROBERT KRETSINGER
EDUCATION
RESEARCH INTERESTS
In collaboration with Julie Sando, Anesthesiology U.VA., we have determined the low resolution, three dimensional structure of protein kinase C  from two dimensional crystals grown on phospholipid monolayers by electron microscopy. We are exploring the occurrence and functions of tandemly repeated sequences whose structures are inherently flexible. We are evaluating the placements of amino acid side chains in protein structures, determined by homology modeling. We are analyzing the concerted changes in conformation that accompany the binding of calcium by proteins in the EF-hand homolog family.
REPRESENTATIVE PUBLICATIONS