CLAIRE CRONMILLER

Professor of Biology

Email: crc2s@virginia.edu

Office: (434) 982-5484

Lab: (434) 982-5485

Office: 260 Gilmer Hall

EDUCATION

A.B., Bryn Mawr College, 1974

Ph.D., Princeton University, 1986

Postdoctoral Research, Princeton University, 1986-1989

RESEARCH INTERESTS

My research interests focus on understanding how complex sequences of differentiation are genetically regulated during development. My primary research uses Drosophila oogenesis as an experimental model fordiscovering basic genetic and cell biological mechanisms that shape multicellular tissues. My lab has taken several experimental approaches to study this process of morphogenesis. Genetically, we identified an extra-ovarian regulatory pathway that we have recently shown involves the function of a metalloprotease, which could be required to activate a long-range signaling molecule. Through a novel pharmacological approach, we uncovered the participation of neural signaling in both follicle formation and maturation. Our current work is aimed at elucidating specific molecular components of these pathways, as well as their biochemical/cellular functions. In addition to my study of tissue morphogenesis, I have established an ongoing collaboration with the laboratory of Dr. David Brautigan (UVA, Center for Cell Signaling) to pursue a related interest in the genetic control of cell division during development. In this work Drosophila genetics is being used to identify cellular functions of important vertebrate regulatory proteins.

REPRESENTATIVE PUBLICATIONS

Ozdowski, E.F., Mowery, Y.M. and Cronmiller, C. (2009) stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation. Genetics 183:1-14.

Wang, W., Cronmiller, C., Brautigan, D. (2008) Maternal phosphatase inhibitor-2 is required for proper chromosome segregation and mitotic synchrony during Drosophila embryogenesis. Genetics 179:1823-1833.

Willard, S.S., Koss, C.M. and Cronmiller, C. (2006) Chronic cocaine exposure in Drosophila : Life, cell death and oogenesis. Developmental Biology 296:150-163.

Willard, S. S., Ozdowski, E. F., Jones, N. A. and Cronmiller, C. (2004) Stall -mediated extrinsic control of ovarian follicle formation in Drosophila. Genetics 168:191-198.

Smith, J.E. III, Cummings, C.A. and Cronmiller, C. (2002) Daughterless coordinates somatic cell proliferation, differentiation and germline cyst survival during follicle formation in Drosophila .Development 129:3255-3267.

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